[slideshare id=5280150&doc=ebm-sum-100924161512-phpapp01]

PICO question: How does the addition of a leukotriene receptor antagonist to low-dose inhaled corticosteroids change the asthma control in children with poorly-controlled asthma, as compared to medium-dose inhaled corticosteroids?

Article: Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids.

Bottom line: This randomized, double-blinded, adequately-powered study showed that kids with poorly-controlled asthma were more significantly likely to respond best to a step up in therapy with LABA (long-acting beta agonist). However, as other patients responded best to step up with ICS (inhaled corticosteroid) or LTRA (leukotriene receptor antagonist), and there have been recent concerns regarding the long-term safety of LABAs, each child should always be managed individually.

Reviewer: Dr. Ada Sum