PICO Question: In infants with bronchiolitis, does nebulized hypertonic saline reduce length of hospital stay compared to supportive care? Article: A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department Bottom line: Although his randomized controlled trial adds to the evidence base, the evidence is not compelling enough to change current practice. Reviewer: Caryn Scoville