[slideshare id=5279805&doc=ebm-headaches-100924152820-phpapp01] PICO question: Does Melatonin have a role in treating chronic headaches in the pediatric population? P: Pediatric population with chronic headaches (migraine or otherwise) I: Melatonin C: Continued care with routine headache therapy O: Improvement in baseline intensity, frequency or duration of headaches Article: Melatonin to prevent migraine or tension-type headache in children Bottom line:Although this was a small non-blinded, non-randomized trial, it is suggestive that melatonin may be a safe and effective intervention for children with multiple forms of chronic headaches. Advances need to be made with a RCT in this area for stronger evidence in the future. Reviewer: Dr. Sarah Lallaman